Best Weight Loss Medications Of 2025

Below are several of the most popular telehealth platforms for obtaining prescription weight loss medications online. Choose the best fit for your goals and lifestyle.

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Our partners may provide compounded medications that have not undergone review or approval by the FDA for safety, quality, or effectiveness. You are encouraged to talk to your provider to determine if a compounded medication is right for you. Medications containing semaglutide, tirzepatide, and liraglutide require a prescription. Only a licensed clinician may prescribe these medications for weight loss if in their clinical judgment use of the product is medically appropriate. These drugs may cause side effects such as nausea, vomiting, diarrhea, abdominal pain, and constipation. Talk to your provider immediately about symptoms. The information provided here is not a substitute for professional medical advice, diagnosis, or treatment and you should not rely upon the content provided here for specific medical advice. If you have any questions or concerns, please talk to your provider.

Our #1 Pick

Calorie-managed diets and exercise have been the mainstay approach of commercial weight loss programs for decades. But as weight loss medications like Ozempic®, Wegovy® and others become household names, people trying to lose weight are exploring adding medications to their weight loss toolkit.

Are Weight Loss Medications Effective?

“Obesity is a condition that affects more than 40% of our adult population and when factoring in candidacy for medications, such as those with overweight and a weight-related condition, the numbers get even higher,” says Anthony Jay Millard, M.D., a board-certified obesity medicine physician at Northwestern Medicine in Chicago. He notes the need for an “all-hands-on-deck approach” with providers across the healthcare spectrum.

Many providers are familiar with the latest weight-loss medications, but not all individuals are candidates for these medications, says Dr. Millard.

Popular Weight Loss Medications

Ozempic®

Ozempic® is an FDA-approved medication for treating type 2 diabetes. Its active ingredient is semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist that acts like the GLP-1 hormone released in the digestive tract when eating. This weight-regulating hormone “signals fullness to the brain, delays stomach emptying and lowers blood sugar,” says Rekha Kumar, chief medical officer at the medically-assisted weight loss program, Found, and practicing endocrinologist in New York City.

The medication is available by prescription only and is used as a weekly injection to help with blood sugar management and help reduce the risk of a heart attack or stroke in people with type 2 diabetes. Since semaglutide has shown effectiveness in reducing body weight for those with overweight or obesity, Ozempic® may also aid in weight loss. However, Ozempic® itself is not FDA approved to treat weight loss alone in patients without a diagnosis of type 2 diabetes.

Wegovy®

Wegovy® is another injectable medication made with semaglutide (the active ingredient in Ozempic®). It’s approved by the FDA for weight management in people with a body mass index or BMI of 27 who have another weight-related condition, such as type 2 diabetes, or those with a BMI of 30 or higher.

Like Ozempic®, Wegovy® is also prescription only and taken once a week.

Saxenda®

Saxenda®, like Ozempic® and Wegovy®, is a GLP-1 receptor agonist, but it’s made with liraglutide (instead of semaglutide). The medication is also prescription-only and FDA-approved for the treatment of obesity in people aged 12 and older who weigh more than 132 pounds or adults with BMI of 30 or higher.

Liraglutide works by helping to decrease appetite and slow the emptying of the stomach, which causes feelings of fullness and leads to lower calorie intake.

Saxenda® is a daily injection, while Ozempic® and Wegovy® are weekly injections.

Weight Loss Medications vs. Fat Burning Pills

Weight loss medications and fat burning pills are vastly different. Fat burning pills and other “quick-fix” weight loss supplements are typically sold over the counter and are not regulated in the same way as weight loss medications. Unlike fat burning pills, weight loss medications require a prescription from a healthcare provider and have been studied extensively for their ability to promote weight management when combined with diet and lifestyle changes.

How to Choose the Best Weight Loss Medication for You

“It is critical that patients remember that these medications are not a magic bullet for weight loss and long-term weight management,” notes Dr. Millard. Nutrition, physical activity, stress and sleep are all critical parts of an optimal weight management plan, he explains, noting that the larger social environment plays a role, too.

With weight issues being so complicated, he points out, “if a provider is suggesting that these medications are a quick fix or only needed for short-term use, that would be a red flag that the chronic nature of obesity is not being considered.” If this occurs, he suggests you find a different provider.

Many people stay on weight loss medications for a few months while working on their diet and exercise routines. Others stay on them indefinitely. Regardless of what you decide medication-wise, exercise and nutrition are essential components of any healthy life, and even small changes can make a big difference over time.

Whether you’re interested in trying weight loss medication, mulling over the idea of joining a commercial weight loss plan or are interested in combining the two, your first stop should be your doctor’s office. Your doctor can discuss the pros and cons of starting medication and help choose the best weight loss medication plan for you.

Sources

Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine. 2021;384(11):989-1002.

†Ozempic® (semaglutide) is a prescription only subcutaneous injection that has not been approved by the FDA as safe and effective to treat obesity and overweight; however, studies have shown that it may be associated with weight loss in individuals with type 2 diabetes.

††Wegovy® (semaglutide) is a prescription-only subcutaneous injection that helps to reduce excess body weight and maintain weight reduction in adults with obesity and adults with overweight and at least one weight-related condition.

†††Zepbound® (tirzepatide) is a prescription-only subcutaneous injection that, when combined with a reduced-calorie diet and exercise, helps to reduce excess body weight and maintain weight reduction in adults with obesity or overweight and at least one weight-related condition, as well as moderate to severe obstructive sleep apnea in adults with obesity.

††††Generic Liraglutide (liraglutide injection) is a prescription-only subcutaneous injection that, as an adjunct to diet and exercise, helps to improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes mellitus.

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